Ofloxacin 200mg & Ornidazole 500mg Tablets Tablet

What is Ofloxacin 200mg & Ornidazole 500mg Tablets Tablet?

Ofloxacin 200 mg and Ornidazole 500 mg Tablets are an oral combination containing an antibacterial agent and an antiprotozoal agent. This tablet formulation is used in the management of certain susceptible bacterial and protozoal infections, subject to appropriate clinical evaluation and the approved product information.

Uses / Indications

• Used in the management of selected susceptible bacterial infections.
• Used for infections where anaerobic or protozoal organisms may be involved.
• May be used in certain gastrointestinal and other infections when this combination is considered appropriate by a qualified healthcare professional.
• Use should be guided by the confirmed diagnosis, susceptibility considerations, and approved product information.

Benefits

• Combines antibacterial and antiprotozoal activity in a single oral dosage form.
• Provides two active ingredients intended to address susceptible bacterial and protozoal organisms.
• Tablet formulation supports convenient oral administration.
• Can be considered where combined antimicrobial coverage is clinically appropriate.

Side Effects

Common Side Effects

Possible side effects may include:

• Nausea or vomiting
• Abdominal discomfort
• Diarrhea
• Headache
• Dizziness
• Changes in taste

Less Common or Serious Side Effects

More serious reactions can occur with ofloxacin-containing medicines and may include tendon problems, peripheral nerve symptoms, significant allergic reactions, severe or persistent diarrhea, or nervous-system effects. Ornidazole may also cause neurological symptoms in uncommon cases.

Seek medical attention if severe allergic symptoms, significant tendon pain or swelling, numbness or tingling, seizures, severe dizziness, or persistent severe diarrhea occurs.

How Does It Work?

Ofloxacin is a fluoroquinolone antibacterial that interferes with bacterial DNA replication by inhibiting bacterial DNA gyrase and topoisomerase IV. Ornidazole is a nitroimidazole antimicrobial that acts against susceptible anaerobic microorganisms and protozoa through formation of reactive metabolites that damage microbial DNA.

Dosage Guidelines

The exact dose and treatment duration should follow the approved product information and the recommendation of a qualified healthcare professional.

Dosage selection may depend on factors such as the type and severity of infection, age, renal function, other medicines being used, and individual clinical circumstances.

Take the tablet exactly as prescribed and swallow it with water. Do not crush, chew, or split the tablet unless this is permitted by the approved product information.

If an overdose is suspected, seek immediate medical attention or contact an appropriate poison-control or emergency medical service.

When Not to Use

This combination should not be used in individuals with known hypersensitivity to ofloxacin, ornidazole, related quinolone or nitroimidazole medicines, or any component of the formulation.

It may also be unsuitable in certain clinical situations, including some conditions involving tendon disorders, significant neurological disease, or specific medication combinations. The approved product information should be reviewed before use.

Drug / Product Interactions

Potential interactions may occur with medicines such as:

• Antacids or mineral supplements containing aluminium, magnesium, calcium, iron, or zinc, which may reduce absorption of ofloxacin when taken too closely together.
• Certain medicines affecting heart rhythm.
• Anticoagulants such as warfarin, which may require monitoring.
• Medicines affecting the central nervous system.
• Other medicines that may increase the risk of tendon or neurological adverse effects.

The complete medication list should be reviewed by a qualified healthcare professional before treatment.

Safety Advice

• Use only according to the prescribed or approved treatment instructions.
• Do not use antibiotics for viral infections unless specifically directed by a healthcare professional.
• Stop activity and seek medical advice if unusual tendon pain or swelling develops.
• Report numbness, tingling, burning sensations, or unusual weakness promptly.
• Avoid driving or operating machinery if dizziness, drowsiness, or impaired coordination occurs.
• Complete the prescribed course unless a qualified healthcare professional advises otherwise.
• Avoid unnecessary self-medication with antimicrobial medicines.

General Instructions

• Take the medicine exactly as directed.
• Swallow the tablet with sufficient water.
• Maintain the prescribed dosing schedule.
• Do not share the medicine with another person.
• Do not use tablets after the expiry date.
• Keep the medicine in its original packaging where possible.

Special Dietary / Lifestyle Tips

• Maintain adequate fluid intake unless fluid restriction has been advised.
• Avoid excessive alcohol consumption during treatment with ornidazole-containing medicines.
• Follow any dietary instructions provided for the underlying infection.
• Maintain good hygiene practices to reduce the risk of transmission of infectious organisms.

Comparison with Other Treatments

Ofloxacin and ornidazole combination tablets provide antibacterial and antiprotozoal components in one dosage form. Other antimicrobial treatments may contain a single active ingredient or a different combination, depending on the causative organism, infection site, susceptibility pattern, patient factors, and approved indications. Selection should therefore be based on clinical assessment rather than formulation alone.

Precautions & Warnings

• Use cautiously in patients with a history of quinolone-associated tendon problems.
• Patients with renal impairment may require appropriate dose consideration.
• Inform the healthcare professional about a history of seizures or neurological disorders.
• Ofloxacin may cause photosensitivity in some individuals; appropriate protection from excessive sunlight may be advisable.
• Report severe or persistent diarrhea during or after treatment.
• Inform the healthcare professional about all prescription medicines, non-prescription medicines, and supplements being used.
• Pregnancy and breastfeeding require appropriate professional evaluation before use.

Can I Use It With Other Medicines?

Generally Compatible With

Compatibility depends on the patient’s complete medication profile. Medicines without significant interaction potential may be used together when prescribed or approved by a qualified healthcare professional.

Use With Caution / Avoid

Particular caution may be required with:

• Antacids and mineral-containing supplements
• Anticoagulants
• Medicines associated with QT-interval prolongation or other heart-rhythm effects
• Medicines affecting the central nervous system
• Other medicines that may increase tendon or neurological adverse effects

A healthcare professional should review the complete medication list before treatment.

Storage

Store according to the storage conditions stated on the approved product label and package insert.

Keep the tablets in the original packaging, protected from excessive heat and moisture, and out of reach of children. Do not use the product after the stated expiry date.

Frequently Asked Questions

1. What is Ofloxacin 200 mg & Ornidazole 500 mg Tablets used for?

It is used for selected bacterial and protozoal infections where the combination is considered clinically appropriate.

2. What are the active ingredients in this tablet?

Each tablet contains Ofloxacin 200 mg and Ornidazole 500 mg.

3. Can this medicine be used without a prescription?

Antimicrobial treatment should be used under the guidance of a qualified healthcare professional because the appropriate medicine depends on the type and cause of infection.

4. Can Ofloxacin and Ornidazole tablets cause dizziness?

Dizziness can occur. Patients who experience dizziness, drowsiness, or impaired coordination should avoid driving or operating machinery and seek appropriate medical advice.

5. Can this tablet be taken with antacids?

Antacids containing aluminium, magnesium, calcium, iron, or zinc may interfere with ofloxacin absorption. Appropriate separation of administration may be required according to the approved product information.

6. What should I do if I miss a dose?

Take the missed dose when remembered unless it is close to the next scheduled dose. Do not take a double dose to compensate. Follow the prescribing instructions for the specific product.

7. Can alcohol be consumed during treatment?

Alcohol consumption should be avoided or minimized during treatment with ornidazole-containing medicines because it may increase the risk of adverse effects.

8. How should these tablets be stored?

Store according to the conditions stated on the approved product label and package insert, and keep the product protected from excessive heat and moisture.