Pregabalin Sr Tablets 75mg, 150mg Tablet

What is Pregabalin Sr Tablets 75mg, 150mg Tablet?

Pregabalin SR Tablets are an extended-release oral formulation containing pregabalin in 75 mg and 150 mg strengths. Pregabalin is used in the management of neuropathic pain and certain other approved neurological conditions. The sustained-release formulation is designed for prolonged drug release according to the approved product information.

Uses / Indications

Pregabalin SR tablets may be used in the management of:

• Neuropathic pain
• Pain associated with diabetic peripheral neuropathy, where indicated
• Post-herpetic neuralgia, where indicated
• Other approved neuropathic pain conditions
• Certain seizure disorders as an adjunctive therapy, depending on the approved indication and formulation

The appropriate indication depends on the patient’s clinical condition and the approved product information.

Benefits

• Provides pharmacological activity relevant to neuropathic pain management.
• May help reduce abnormal nerve-related pain sensations.
• Available in 75 mg and 150 mg strengths.
• Sustained-release formulation provides prolonged drug release according to the approved product specification.
• May be used for specific neurological indications when clinically appropriate.

Side Effects

Common Side Effects

Possible adverse effects may include:

• Dizziness
• Sleepiness or drowsiness
• Headache
• Dry mouth
• Blurred vision
• Fatigue
• Peripheral oedema
• Increased appetite
• Weight gain

Less Common or Serious Side Effects

Clinically important reactions may include:

• Severe dizziness or excessive sedation
• Confusion or changes in mental status
• Hypersensitivity or allergic reactions
• Angioedema
• Breathing difficulties, particularly in patients with respiratory risk factors or when combined with other medicines that depress the central nervous system
• Significant swelling

Medical attention should be sought if severe allergic, respiratory, neurological, or other serious symptoms develop.

How Does It Work?

Pregabalin

Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. This reduces the release of several excitatory neurotransmitters involved in abnormal neuronal signalling, helping to reduce neuropathic pain and excessive neuronal activity.

The sustained-release formulation is designed to release pregabalin over an extended period according to the approved product specification.

Dosage Guidelines

The appropriate dose and treatment duration depend on the indication, clinical response, age, kidney function, other medicines and individual patient factors.

The exact dose and treatment duration should follow the approved product information and the recommendation of a qualified healthcare professional.

For SR tablets:

• Take exactly as prescribed.
• Follow the administration instructions for the sustained-release formulation.
• Swallow the tablet whole with sufficient water unless otherwise directed.
• Do not crush, chew, or alter the sustained-release tablet unless permitted by the approved product information.
• Do not discontinue treatment abruptly without professional advice, particularly when used for seizure-related indications.
• Dose adjustment may be necessary in patients with impaired renal function.

When Not to Use

Pregabalin should generally not be used in patients with a known hypersensitivity to pregabalin or any component of the formulation.

Medical advice is particularly important in patients with:

• Renal impairment
• Respiratory disorders
• A history of drug hypersensitivity
• Conditions associated with significant dizziness or falls
• A history of substance misuse or dependence

Drug / Product Interactions

Pregabalin has relatively limited pharmacokinetic interactions, but clinically important additive effects may occur with medicines that depress the central nervous system.

Particular caution may be required with:

• Opioids
• Sedative or hypnotic medicines
• Other central nervous system depressants
• Medicines that may increase the risk of dizziness or impaired coordination

Patients taking multiple medicines should inform their healthcare professional before starting treatment.

Safety Advice

Overdose

If an overdose is suspected, seek immediate medical attention or contact an appropriate poison-control or emergency medical service.

Overdose may cause symptoms such as marked drowsiness, confusion, agitation, reduced consciousness or other central nervous system effects.

Missed Dose

Take the missed dose when remembered according to the approved dosing instructions unless it is nearly time for the next scheduled dose. If the next dose is due soon, follow the prescribed schedule rather than taking an extra dose. Do not double the next dose unless specifically instructed by a healthcare professional.

Pregnancy

Pregabalin should be used during pregnancy only after appropriate medical assessment. Healthcare professionals should evaluate the potential benefits and risks before use.

Breastfeeding

Pregabalin can pass into breast milk. The decision to use pregabalin during breastfeeding should be discussed with a qualified healthcare professional.

Children

Use in children should follow the age-specific recommendations of the approved product information. The safety and suitability of a sustained-release formulation should be established before use.

Elderly Patients

Older patients may be more susceptible to dizziness, drowsiness and falls. Renal function should also be considered when determining the appropriate dose.

Renal Impairment

Pregabalin is primarily eliminated through the kidneys. Dose adjustment may therefore be required in patients with impaired renal function.

Driving and Operating Machinery

Pregabalin may cause dizziness, drowsiness or blurred vision. Patients should avoid driving or operating machinery if these effects impair their ability to do so safely.

General Instructions

• Take the medicine exactly according to the prescribed schedule.
• Swallow the sustained-release tablet whole unless the approved product information permits otherwise.
• Do not crush or chew the tablet unless specifically permitted.
• Do not alter the prescribed dose without professional advice.
• Avoid activities requiring full alertness if dizziness or drowsiness occurs.
• Do not share prescription medicines with other people.
• Follow the approved product information and healthcare professional’s instructions.

Special Dietary / Lifestyle Tips

No specific dietary restriction is generally required unless advised by a healthcare professional.

Patients experiencing dizziness or drowsiness should take appropriate precautions with driving, machinery and activities requiring alertness. Alcohol and other sedating substances may increase central nervous system effects and should be discussed with a healthcare professional.

Comparison with Other Treatments

Pregabalin is a gabapentinoid medicine used for conditions involving abnormal nerve signalling. Other treatments for neuropathic pain may include different drug classes, such as certain antidepressants or other anticonvulsant medicines.

Treatment selection depends on the underlying condition, symptoms, concurrent medicines, kidney function, tolerability and the approved indication. Sustained-release and immediate-release formulations may also differ in their administration schedules and release characteristics.

Precautions & Warnings

• Confirm any history of hypersensitivity to pregabalin or formulation components.
• Use cautiously in patients with renal impairment.
• Monitor for dizziness, drowsiness and impaired coordination.
• Exercise caution in elderly patients who may have an increased risk of falls.
• Consider respiratory risk, particularly when pregabalin is used with opioids or other central nervous system depressants.
• Monitor patients for significant swelling or other clinically important adverse reactions.
• Patients with a history of substance misuse should be appropriately monitored.
• Do not discontinue treatment abruptly without professional guidance.
• Use during pregnancy or breastfeeding should be based on appropriate medical assessment.

Can I Use It With Other Medicines?

Generally Compatible With

Pregabalin can be prescribed alongside various medicines when clinically appropriate. Its suitability depends on the patient’s complete medication profile and medical condition.

Use With Caution / Avoid

Particular caution may be required when pregabalin is combined with:

• Opioid medicines
• Sedatives
• Hypnotic medicines
• Other central nervous system depressants
• Medicines that may contribute to dizziness or impaired coordination

Patients should inform their healthcare professional about all prescription medicines, non-prescription medicines and other products they are using.

Storage

Store according to the storage conditions stated on the approved product label and package insert.

• Keep properly closed.
• Protect from excessive heat.
• Protect from moisture.
• Keep out of reach of children.
• Do not use after the expiry date.
• Keep in the original packaging where appropriate.

Frequently Asked Questions

1. What are Pregabalin SR Tablets 75 mg and 150 mg used for?

Pregabalin SR tablets may be used in the management of neuropathic pain and certain other approved neurological conditions, depending on the product indication.

2. What are the available strengths of Pregabalin SR Tablets?

The supplied product is available in 75 mg and 150 mg strengths.

3. How does Pregabalin work?

Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels and reduces the release of certain excitatory neurotransmitters involved in abnormal nerve signalling.

4. How should Pregabalin SR Tablets be taken?

They should be taken exactly as prescribed. Sustained-release tablets should generally be swallowed whole with sufficient water unless the approved product information states otherwise.

5. Can Pregabalin be used in patients with kidney problems?

Patients with renal impairment may require dose adjustment because pregabalin is primarily eliminated through the kidneys. The appropriate regimen should be determined by a healthcare professional.

6. Can Pregabalin cause drowsiness or dizziness?

Yes. Dizziness and drowsiness are among the commonly reported adverse effects. Patients should use caution with driving or operating machinery if these effects occur.

7. Can Pregabalin be taken with other medicines?

Pregabalin may be used with other medicines when clinically appropriate, but caution may be required with opioids, sedatives and other central nervous system depressants.

8. How should Pregabalin SR Tablets be stored?

Store the product according to the conditions stated on the approved product label and package insert, and keep it out of reach of children.